The Medical Management of Interstitial Pregnancy: A Case Series and Literature Review
Billie Frederix, Martine Dehandschutter and Frédéric Buxant
Introduction: Interstitial pregnancies are a rare form of ectopic pregnancy, and their diagnosis and
treatment can be challenging.
Results: This case series presents three cases of interstitial pregnancies successfully treated with
intramuscular methotrexate.
Conclusion: Methotrexate is an effective treatment for interstitial pregnancies, even in cases with high
β-hCG levels or fetal cardiac activity. For patients who can be closely monitored, medical treatment
provides a good alternative to surgery.
