Relationship Between Artificial Sweeteners Intake With Diabetes in Experimental Rats
Norah Abdullah Mohammed Fahad Al-Hazzaa, Abdelrahman R Ahmed
The artificial sweeteners have been used in many food industries and young and adults' ones accept the
taste of very sweet taste and low calories compared to natural sweeteners and became marketed on the
basis that it is possible to control and reduce diabetes and the effects of these artificial sweeteners, But
the manufacturers are unaware of the side effects that may be caused in the long term.
Methods: The current research was carried out to know the effect of artificial sweeteners on low blood
sugar in experimental rats. For this purpose, rats were divided to three groups with adding different
artificial sweeteners (Aspartame, sucralose, saccharine) at the same dose level (10 gm/kg fed basal); the
control group of rats was fed a basal diet without any sweeteners for 8 weeks.
Results: The feeding of rats on sucralose and aspartame led to a high significant with statistically
significant increase in the level of Blood glucose (125±7 mg/dL, 123±10 mg/dL) compared to the control
group, while the saccharin group was not affected by the blood glucose level after the 8 weeks study
period.
Conclusion: It was concluded that artificial sweeteners had an effect on increasing blood glucose levels
in male rats, and therefore they could not be included in the diets, especially for diabetic patients.
