Effective Supplementation With Micronutrients in a Patient With Non-Obstructive Azoospermia and Varicocele: A Case Report
Adib Ziade, Patrick Choueiry
Background: Non-obstructive azoospermia (NOA) is a form of male infertility, often associated with
conditions influencing spermatogenesis, such as varicoceles. While varicocele repair is a standard
intervention, the role of micronutrient supplementation in improving semen parameters and enhancing
fertility outcomes in men with NOA and varicocele is promising.
Case Summary: The patient is a 30-year-old white Lebanese Caucasian male presenting with a previous
diagnosis of NOA, with low testosterone levels and elevated follicle-stimulating hormone and luteinizing
hormone levels. Clinical examination, hormonal assessment, scrotal ultrasound, and semen analysis
revealed non-obstructive azoospermia associated with bilateral varicoceles. After ongoing bilateral
varicocelectomy, the patient was prescribed Cyclofert MaleTM, a combination of L-carnitine L-tartrate,
N-acetyl-cysteine, coenzymeq10, Zinc, folic acid, selenium, vitamin C, vitamin E, and Lycopene, at
a dose of two tablets per day, for six months. At follow-up, semen analysis revealed improved sperm
concentration; and successful in vitro fertilization (IVF) with blastocyst transfer was achieved.
Conclusion: This case reveals the potential role of micronutrient supplementation in improving semen
parameters and IVF outcomes. Cyclofert MaleTM offers a promising adjunctive and non-invasive
treatment option for men with NOA and infertility.
