Effect of Myo-Inositol in Combination with Alpha-Lipoic Acid and Cysteine (CelineTM) Based Co-Treatment on Oocyte Quality in Women with Polycystic Ovarian Syndrome Undergoing Assisted Reproductive Technology
Jehan Elfarjani, Patrick Choueiry
Background: Myo-inositol (MI), alone or in combination, has gained attention as a potential adjuvant
therapy in women undergoing assisted reproductive techniques (ART). The aim of this study was to
evaluate the effects of MI in combination with alpha-lipoic (ALA) and N-acetylcysteine (NAC) on oocyte
quality and ART outcomes in women with polycystic ovary syndrome (PCOS).
Methods: A total of 100 women with PCOS, aged 20-40 years and undergoing ART were randomly
assigned to either the MI-ALA-NAC group (n=50) or the control group (n=50). The intervention group
received daily oral supplementation of CelineTM (MI in combination with ALA and NAC) in addition to
folic acid (FA) supplementation and standard ART treatment, while the control group received FA only
in addition to standard treatment. The primary outcome measures included preovulatory follicle count,
the number of mature oocytes retrieved, and embryo quality. The secondary outcomes were the number
of gonadotropin vials used, ovarian stimulation duration, and pregnancy rate.
Results: The Celine group demonstrated a significantly greater number of large sized follicles, oocytes
retrieved, mature oocytes and improved embryo quality (p<0.05). Additionally, the Celine group
exhibited shorter stimulation duration, reduced gonadotropin dose required, and higher pregnancy rate
(p<0.005).
Conclusions: MI in combination with ALA and NAC as an adjunct to ART among women with PCOS
showed promising results in improving reproductive outcomes. Future studies should aim to expand our
understanding of the long-term effects, and refine the clinical application of this MI co-treatment as an
adjunct therapy in fertility clinics to improving the success rates and overall effectiveness of fertility
treatments.
Trial registration: PACTR, PACTR202401759325189. Registered 16 January 2024 - Retrospectively
registered, https://pactr.samrc.ac.za/Search.aspx
