Application And Comparison of Various Mouse Models in Liver Cancer Research
Yinuo Wang, Yajie Wang, Mei Feng
Liver cancer remains a significant global health burden, necessitating robust preclinical models to study
its pathophysiology and develop effective therapies. This review explores the utilization and comparative
effectiveness of various mouse models in liver cancer research, including subcutaneous tumor models,
orthotopic tumor models, spontaneous models, and humanized models. Each model's relevance to
mimicking human liver cancer pathophysiology and its implications for therapeutic development are
discussed. The strengths and limitations of each model are highlighted, providing insights into their
suitability for specific research objectives.
