TY  - JOUR
AU  - Stanisław Ostrowski
AU  - Sylwia Ostrysz
PY  - 2026
DA  - 2026/04/21
TI  - Synthesis of β-Hexasubstituted Porphyrins by Vicarious Nucleophilic Substitution of Hydrogen. Closing Research
JO  - Japan Journal of Research
VL  - 7
IS  - 3
AB  - Meso-Tetraarylporphyrin chelates in the electrophilic reactions with nitric acid, under optimized
conditions, can give mainly β,β,β-trinitro-substituted moieties. These intermediates (Cu2+- and Zn2+-
derivatives; obtained in overall yields of up to 38%), upon the reaction with carbanions bearing a
leaving group X at the reactive centre afford the target products, the ones of vicarious nucleophilic
substitution of hydrogen (VNS). This approach allows the synthesis of hydrophilic or amphiphilic
porphyrin derivatives exhaustively β-substituted in three pyrrole rings that seem to be potential agents
in anticancer photodynamic therapy (PDT). The above two-step procedure including very attractive
VNS reaction leads to moieties practically unavailable by alternative methods.
SN  - 2690-8077
UR  - https://dx.doi.org/10.33425/2690-8077.1232
DO  - 10.33425/2690-8077.1232