TY  - JOUR
AU  - Marjan Assefi
AU  - Sahar Asvadi
AU  - Hossein Ghahramani Almanghadim
AU  - Fatemeh Zeinali Sehrig
AU  - Zahra Foruzandeh
AU  - Shahab Masoumi
AU  - Hadis Sheikhi
PY  - 2021
DA  - 2021/07/18
TI  - Potential Clinical Usefulness of CRISPR Cas9 Genome Editing in Cancer Treatment
JO  - Biomedical and Translational Science
VL  - 1
IS  - 2
AB  - Cancer is still considered a main challenge regarding morbidity and mortality, although an earlier
diagnosis through screening programs and more effective cure modalities have led to decreased mortality
rates so the development of new genetic editing techniques such as zinc finger and TALENs or CRISPRCas9 has enabled the production of strong animal genetic models that sums up the cooperating oncogenic
lesions influencing genes with a confirmed role in the proliferation and formation. This review presents
the mechanisms of separate genome-editing approaches and explains each of the common nucleasebased platforms.
SN  - 2768-4911
UR  - https://dx.doi.org/10.33425/2768-4911.1010
DO  - 10.33425/2768-4911.1010