TY - JOUR AU - Benedetto Massimo AU - Fazio Giovanni PY - 2021 DA - 2021/08/25 TI - Left atrial appendage closure with device for atrial fibrillation JO - Biomedical and Translational Science VL - 1 IS - 3 AB - Atrial fibrillation is the most common observed arrhythmia in clinical practice and it represents an important risk factor for cardio-embolism and cardio-embolic stroke. Atrial fibrillation patients have a 5 fold increase in stroke events. In non-valvular atrial fibrillation over 90% of thrombus formation is within the left atrial appendage and therefore prevention of embolization to systemic circulation and in particular to cerebral circulation goes through a therapy that has the left atrial appendage as the main target. Several anatomo-pathological studies and observations during open heart surgery confirm these data and give a rational basis to this point of view SN - 2768-4911 UR - https://dx.doi.org/10.33425/2768-4911.1014 DO - 10.33425/2768-4911.1014