Hormonal Imbalances and Obsessive-Compulsive Disorder
Eda Gorbis, Alexander Gorbis, Amanda Rudolph, Aanya Jajoo
Obsessive-compulsive disorder (OCD) is a chronic mental health condition marked by intrusive
thoughts and repetitive behaviors, significantly impairing daily functioning. This paper investigates the
relationship between hormonal imbalances and OCD by reviewing existing literature and presenting
detailed case studies. The analysis focuses on the impact of hormonal fluctuations, particularly involving
estrogen, androgens, progesterone, melatonin, and cortisol, on the onset and severity of OCD symptoms.
Case studies of individuals with polycystic ovary syndrome (PCOS), postpartum hormonal changes, and
post-hysterectomy hormonal shifts illustrate how hormonal imbalances can exacerbate OCD symptoms.
The findings indicate that hormonal events, such as premenstrual periods and pregnancy, can trigger or
worsen OCD symptoms in approximately 30% of women. Hormone replacement therapy and targeted
hormonal interventions show promise in alleviating OCD symptoms, suggesting a potential for hormonebased treatment approaches. This study underscores the need for a comprehensive understanding of
hormonal influences in managing OCD to enhance treatment outcomes and improve patients' quality
of life.
