Effects of FermixTM Administration on Hematological Parameters and Physical Symptoms Among Patients With Iron Deficiency or Iron Deficiency Anemia: A Retrospective Chart Review
Introduction: Iron deficiency (ID) and Iron deficiency anemia (IDA) is a common nutritional disorder
characterized by low iron levels, resulting in reduced production of healthy red blood cells. While iron
supplementation is commonly used in the treatment of IDA, there is limited research on the effects of
combined supplementation with other minerals and vitamins.
Objectives: This study aims to investigate the effects of a combination of iron, magnesium, folic acid,
and vitamins C, D, B6 and B12 on hematological outcomes such as hemoglobin, mean corpuscular
volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration
(MCHC), and ferritin levels as well as on physical symptoms, specifically fatigue and headache in
patients diagnosed with ID and IDA. The effect of magnesium in combination on symptoms of magnesium
deficiency, such as muscle cramps, was also studied in this specific population.
Methods: We reviewed the medical records of 34 patients with ID/IDA at baseline and follow-up after
4 months of FermixTM supplementation, which is a combination of liposomal iron pyrophosphate,
magnesium, folic acid, vitamin D, C, B6, and B12. Hematological parameters and physical symptoms
were compared between baseline and follow-up using paired samples t-test and McNemar chi-square
test.
Results: A total of 34 patients were included. After FermixTM supplementation, significant improvements
were observed in hemoglobin, MCV, MCH, MCHC, and ferritin levels. There was also a significant
improvement in the frequency and intensity of headache, fatigue, and muscle cramps.
Conclusions: Our results highlight the beneficial effects of iron supplementation combined with
magnesium, folic acid, and vitamins C, D, B6, and B12 in improving hematological parameters and
alleviating physical symptoms in patients with ID/IDA.
