This observational real-world study was conducted on 14 patients who needed a minor office surgery
or procedure and who were eligible for a COVID-19 booster according to the French Health Agency.
The aim of the study was focused on biological markers which might have an incidence after surgery.
The platelet count, D-dimer level, and anti-spike IgG antibodies levels, were the numeric parameters
studied. The study showed no perturbation in the platelet count. Conversely, we observed an abnormal
elevation of D-dimer levels in 4 patients (28 %). The most remarkable data was the constant residual
positive level anti-spike IgG antibodies observed in all patients after 6 months ranging from 44 to 5680
BAU/mL. For these reasons, further studies on a bigger cohort would be useful to clarify the possible
incidence of COVID-19 vaccines on D-dimer levels and a monitoring of the immune response should be
proposed to all patients eligible for a SARS-CoV-2 vaccine booster in order to evaluate the benefit-risk
ratio of this injection.
