Hydrogel particles for biomarker detection in liquid biopsies
Shoichiro Sueoka and Frederic Zenhausern
In this brief review we assessed the recent progress of hydrogel materials design and processing for
applications in biomarker sensing for early diseases diagnosis and potential clinical use. Three types
of hydrogel platforms were identified that can be classified in the following categories: (i) fluorescence
hydrogel biosensing platform, (ii) integrated electrochemical biosensor systems and (iii) synthetic
core-shell hydrogel for biological specimen manipulation. In each type of these approaches, hydrogel
materials were functionalized with features suitable for liquid biopsy application. These features can
comprise high conductivity, biocompatibility, ease-of-use, robustness, but also anti-fouling properties.
The properties of these nanomaterials will enable them into promising tools in precision medicine.
