Due to the technical difficult in built up a stable vaccine against some viruses whose structure change
with multiple mutations, the possibility of overcoming the problem could be an indirect approach. As
proposed by some authors, the system medicine science suggests the possibility to act counteracting
the mechanism induced by the pathogen rather than acts directly against the virus exploiting the
hormesis phenomenon. Indeed, most of the COVID-19 fatalities are a consequence of the cytokine
storm because of the strong oxidative stress and inflammation induced by an exaggerated response of
the immune system. While a vaccine is addressed to simulate the image of the virus and to induce a
humoral protection, the indirect approach trough a mild oxidative stress simulates the effect induced by
the virus itself promoting the activation of defence mechanisms which in turn could favor the healing
of the patients.
